Native-State Structural Analysis of Respiratory Syncytial Virus
نویسندگان
چکیده
Human respiratory syncytial virus (hRSV) is an enveloped RNA virus that belongs to Paramyxoviridae family. HRSV is the most common cause of bronchiolitis and pneumonia in young children in the United States, and severe infections of infants and immuno-compromised adults can lead to death. In order to characterize the molecular mechanisms underlying hRSV assembly and viral and host cellular protein dynamics at high spatiotemporal resolution, we use cryo-electron tomography (cryo-ET) and cryo-correlative light and electron microscopy (cryo-CLEM) to examine hRSV-infected cells.
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